13.11.2016 | 5:35 PM
2013 ETA Guideline: Management of Subclinical Hypothyroidism. PMID: 24783053

Simon H.S. Pearce, Georg Brabant, Leonidas H. Duntas, Fabio Monzani e Robin P. Peeters, Salman Razvi, Jean-Louis Wemeau European Thyroid Journal, 2013 Abstract Subclinical hypothyroidism (SCH) should be considered in two categories according to the elevation in serum thyroid-stimulating hormone (TSH) level: mildly increased TSH levels (4.0-10.0 mU/l) and more severely increased TSH value (>10 […]

21.10.2016 | 4:35 PM
For hypothyroid patients on levothyroxine “a normal TSH” might not be enough. PMID: 2770053

Hypothyroidism affects more than 10 million Americans, mostly women, and hundreds of millions worldwide. For 90 years since the first cases were described, hypothyroid patients were treated with capsules containing desiccated animal thyroid. With the discovery in the 1970s that deiodinases convert T4 to T3 in humans and the development of a method to measure […]

04.10.2016 | 5:32 PM
Is a normal TSH synonymous with “euthyroidism” in levothyroxine monotherapy? PMID: 27700539

Context: Levothyroxine (LT4) monotherapy is the standard of care for hypothyroidism. Objective: To determine whether LT4 at doses that normalize the serum TSH is associated with normal markers of thyroid status. Design: Cross-sectional data from the US National Health and Nutrition Examination Survey (2001-2012) was used to evaluate 52 clinical parameters. LT4-users were compared to […]

26.08.2016 | 12:29 PM
Depression due to deiodinase defect, despite normal thyroid hormone levels. PMID: 27501182

The World Health Organization estimates that about 450 million people worldwide suffer from depression. Depression is characterized by low mood, decreased interest in daily activities, fatigue, insomnia, sorrow, and in the worst cases thoughts of death. Depression can be caused by hormonal imbalance and is not rare in patients with hypothyroidism. This is because thyroid […]

12.08.2016 | 5:45 PM
Hypothyroidism: An Update. PMID: 22962987

Gaitonde DY, Rowley KD, Sweeney LB. American Family Physician, Volume 86, Number 3 August 1, 2012 Abstract Hypothyroidism is a clinical disorder commonly encountered by the primary care physician. Untreated hypothyroidism can contribute to hypertension, dyslipidemia, infertility, cognitive impairment, and neuromuscular dysfunction. Data derived from the National Health and Nutrition Examination Survey suggest that about […]

12.08.2016 | 11:04 AM
Type 2 deiodinase disruption in astrocytes results in anxiety-depressive-like behavior in male mice. PMID: 27501182

Millions of levothyroxine-treated hypothyroid patients complain of impaired cognition despite normal TSH serum levels. This could reflect abnormalities in the type-2 deiodinase (D2)-mediated T4-to-T3 conversion, given their much greater dependence on the D2 pathway for T3 production. T3 normally reaches the brain directly from the circulation or is produced locally by D2 in astrocytes. Here […]

08.07.2016 | 2:27 PM
Physical exercise activates thyroid hormone in skeletal muscle. PMID: 27302464

All of us benefit from regular physical exercise. Indeed, exercise is recommended at all ages, from children to elderly, as an inexpensive way of maintaining and improving health and wellbeing. In addition, patients with conditions such as diabetes, obesity, depression and myocardial infarction also benefit from appropriate regimens of exercise. However, it was not until […]

23.06.2016 | 12:21 PM
Thyroid hormone activation by type 2 deiodinase mediates exercise-induced PGC-1a. PMID: 27302464

Thyroid hormone (TH) promotes expression of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a), which mediates mitochondrial biogenesis and oxidative capacity in skeletal muscle (SKM). Skeletal myocytes express the type 2 deiodinase (D2), which generates T3, the active TH. To test whether D2-generated T3 plays a role in exercise-induced PGC-1a expression, male rats and mice with […]

17.05.2016 | 11:38 AM
New studies could impact treatment recommendations for hypothyroidism. PMID: 25555216

The thyroid gland produces two hormones, T4 (poorly active) and T3 (most active). The pituitary gland constantly monitors the circulating levels of T4 and T3, secreting TSH whenever the levels of either hormone drops below a certain threshold. Hypothyroidism is a condition in which the thyroid gland does not function adequately due to inflammation (e.g. […]

15.05.2016 | 8:34 PM
The ATA handbook to investigate thyroid hormone economy and action.

Abstract Background: An in-depth understanding of the fundamental principles that regulate thyroid hormone homeostasis is critical for the development of new diagnostic and treatment approaches for patients with thyroid disease. Summary: Important clinical practices in use today for the treatment of patients with hypothyroidism, hyperthyroidism, or thyroid cancer, are the result of laboratory discoveries made […]