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09.02.2017 | 1:13 AM
2017 American Thyroid Association Hypothyroidism Treatment Survey
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Take the survey now!   This survey for patients with hypothyroidism has been organized by the American Thyroid Association. The results will be presented and discussed by a panel of expert physicians, scientists, and patients with hypothyroidism at the organization’s symposium in Orlando, FL later this spring. By completing this short survey, you will help […]

23.01.2017 | 5:08 PM
The unexpected hypothyroid heart in patients with normal TSH levels. PMID: 28095748
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The heart of patients with stenosis of the aortic valve inactivates thyroid hormone and causes localized hypothyroidism in otherwise euthyroid individuals with normal TSH and thyroid hormones levels. This was found in a group of 23 patients with aortic stenosis that underwent corrective surgery. A second group of 35 patients with coronary artery disease undergoing […]

23.01.2017 | 4:36 PM
Myocardial inactivation of thyroid hormones in patients with aortic stenosis. PMID: 28095748
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Objective: To study myocardial thyroid hormone metabolism in patients with aortic valve stenosis (AS) undergoing aortic valve replacement and in patients with coronary artery disease (CAD) undergoing coronary artery bypass grafting surgery. Context: The human heart expresses the type 2 deiodinase (D2) that activates T4 to T3. At the same time, the inactivating type 3 […]

03.12.2016 | 5:44 PM
Developmental disruption of type 2 deiodinase in skeletal muscle does not impair muscle function. PMID: 27967605
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Background: Myogenesis is positively regulated by thyroid hormone (T3), which is amplified by the type 2 deiodinase (D2) activation of T4-to-T3. Global inactivation of Dio2 gene impairs skel-etal muscle (SKM) differentiation and regeneration in response to muscle injury. Given that new-born and adult mice with late developmental SKM Dio2 disruption do not develop a significant […]

13.11.2016 | 5:35 PM
2013 ETA Guideline: Management of Subclinical Hypothyroidism. PMID: 24783053
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Simon H.S. Pearce, Georg Brabant, Leonidas H. Duntas, Fabio Monzani e Robin P. Peeters, Salman Razvi, Jean-Louis Wemeau European Thyroid Journal, 2013 Abstract Subclinical hypothyroidism (SCH) should be considered in two categories according to the elevation in serum thyroid-stimulating hormone (TSH) level: mildly increased TSH levels (4.0-10.0 mU/l) and more severely increased TSH value (>10 […]

21.10.2016 | 4:35 PM
For hypothyroid patients on levothyroxine “a normal TSH” might not be enough. PMID: 2770053
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Hypothyroidism affects more than 10 million Americans, mostly women, and hundreds of millions worldwide. For 90 years since the first cases were described, hypothyroid patients were treated with capsules containing desiccated animal thyroid. With the discovery in the 1970s that deiodinases convert T4 to T3 in humans and the development of a method to measure […]

04.10.2016 | 5:32 PM
Is a normal TSH synonymous with “euthyroidism” in levothyroxine monotherapy? PMID: 27700539
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Context: Levothyroxine (LT4) monotherapy is the standard of care for hypothyroidism. Objective: To determine whether LT4 at doses that normalize the serum TSH is associated with normal markers of thyroid status. Design: Cross-sectional data from the US National Health and Nutrition Examination Survey (2001-2012) was used to evaluate 52 clinical parameters. LT4-users were compared to […]

26.08.2016 | 12:29 PM
Depression due to deiodinase defect, despite normal thyroid hormone levels. PMID: 27501182
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The World Health Organization estimates that about 450 million people worldwide suffer from depression. Depression is characterized by low mood, decreased interest in daily activities, fatigue, insomnia, sorrow, and in the worst cases thoughts of death. Depression can be caused by hormonal imbalance and is not rare in patients with hypothyroidism. This is because thyroid […]

12.08.2016 | 5:45 PM
Hypothyroidism: An Update. PMID: 22962987
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Gaitonde DY, Rowley KD, Sweeney LB. American Family Physician, Volume 86, Number 3 August 1, 2012 Abstract Hypothyroidism is a clinical disorder commonly encountered by the primary care physician. Untreated hypothyroidism can contribute to hypertension, dyslipidemia, infertility, cognitive impairment, and neuromuscular dysfunction. Data derived from the National Health and Nutrition Examination Survey suggest that about […]

12.08.2016 | 11:04 AM
Type 2 deiodinase disruption in astrocytes results in anxiety-depressive-like behavior in male mice. PMID: 27501182
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Millions of levothyroxine-treated hypothyroid patients complain of impaired cognition despite normal TSH serum levels. This could reflect abnormalities in the type-2 deiodinase (D2)-mediated T4-to-T3 conversion, given their much greater dependence on the D2 pathway for T3 production. T3 normally reaches the brain directly from the circulation or is produced locally by D2 in astrocytes. Here […]