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29.04.2018 | 10:48 PM
Hypothyroidism. PMID: 28336049
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Hypothyroidism is a common condition of thyroid hormone deficiency, which is readily diagnosed and managed but potentially fatal in severe cases if untreated. The definition of hypothyroidism is based on statistical reference ranges of the relevant biochemical parameters and is increasingly a matter of debate. Clinical manifestations of hypothyroidism range from life-threatening to no signs or symptoms. The […]

26.04.2018 | 9:27 PM
Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia. PMID: PMID: 29320745
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Liver-specific disruption of the type 2 deiodinase gene (Alb-D2KO) results in resistance to both diet-induced obesity and liver steatosis in mice. Here, we report that this is explained by an about 60% reduction in liver zinc-finger protein-125 (Zfp125) expression. Zfp125 is a Foxo1-inducible transcriptional repressor that causes lipid accumulation in the AML12 mouse hepatic cell […]

25.04.2018 | 10:54 AM
A DIO2 Polymorphism And Alzheimer’s Disease Dementia in African And European Americans. PMID: 29481662
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CONTEXT: A single nucleotide polymorphism in DIO2, Thr92AlaD2, has been associated with a transcriptome typically found in neurodegenerative diseases in postmortem human brain tissue. OBJECTIVE: To determine whether Thr92AlaD2 is associated with incident Alzheimer’s disease (AD). DESIGN: Population-based study; human brain tissue microarray. SETTING: Community-based cohorts from Chicago, Illinois and northeastern Illinois, as well as […]

20.04.2018 | 2:11 PM
An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction. PMID: 29620972
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Approximately 15% more patients taking levothyroxine (LT4) report impaired quality of life compared to controls. This could be explained by additional diagnoses independently affecting the quality of life and complicating assignment of causation. This study sought to investigate the underpinnings of reduced quality of life in hypothyroid patients and to provide data for discussion at […]

20.04.2018 | 1:51 PM
Results of the 2017 Spring survey of hypothyroid patients – 12,146 individuals responded
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Current guidelines recommend daily tablets of levothyroxine at doses that normalize blood levels of TSH to treat hypothyroidism but some patients remain symptomatic despite treatment. These patients may complain of sluggishness, lethargy, sleepiness, memory problems, depression, cold intolerance, hoarseness, dry skin, body weight gain, and constipation; patients may also change physicians multiple times in pursuit […]

09.02.2017 | 1:13 AM
2017 American Thyroid Association Hypothyroidism Treatment Survey
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Take the survey now!   This survey for patients with hypothyroidism has been organized by the American Thyroid Association. The results will be presented and discussed by a panel of expert physicians, scientists, and patients with hypothyroidism at the organization’s symposium in Orlando, FL later this spring. By completing this short survey, you will help […]

23.01.2017 | 5:08 PM
The unexpected hypothyroid heart in patients with normal TSH levels. PMID: 28095748
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The heart of patients with stenosis of the aortic valve inactivates thyroid hormone and causes localized hypothyroidism in otherwise euthyroid individuals with normal TSH and thyroid hormones levels. This was found in a group of 23 patients with aortic stenosis that underwent corrective surgery. A second group of 35 patients with coronary artery disease undergoing […]

23.01.2017 | 4:36 PM
Myocardial inactivation of thyroid hormones in patients with aortic stenosis. PMID: 28095748
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Objective: To study myocardial thyroid hormone metabolism in patients with aortic valve stenosis (AS) undergoing aortic valve replacement and in patients with coronary artery disease (CAD) undergoing coronary artery bypass grafting surgery. Context: The human heart expresses the type 2 deiodinase (D2) that activates T4 to T3. At the same time, the inactivating type 3 […]

03.12.2016 | 5:44 PM
Developmental disruption of type 2 deiodinase in skeletal muscle does not impair muscle function. PMID: 27967605
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Background: Myogenesis is positively regulated by thyroid hormone (T3), which is amplified by the type 2 deiodinase (D2) activation of T4-to-T3. Global inactivation of Dio2 gene impairs skel-etal muscle (SKM) differentiation and regeneration in response to muscle injury. Given that new-born and adult mice with late developmental SKM Dio2 disruption do not develop a significant […]

13.11.2016 | 5:35 PM
2013 ETA Guideline: Management of Subclinical Hypothyroidism. PMID: 24783053
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Simon H.S. Pearce, Georg Brabant, Leonidas H. Duntas, Fabio Monzani e Robin P. Peeters, Salman Razvi, Jean-Louis Wemeau European Thyroid Journal, 2013 Abstract Subclinical hypothyroidism (SCH) should be considered in two categories according to the elevation in serum thyroid-stimulating hormone (TSH) level: mildly increased TSH levels (4.0-10.0 mU/l) and more severely increased TSH value (>10 […]