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03.11.2018 | 6:06 PM
Thyroid Hormone Status During L-T4 Therapy: Systematic Review and Meta-Analysis. PMID: 30124904
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Importance: The standard of care for overt hypothyroidism is levothyroxine at doses that normalize serum TSH levels. This approach may not universally restore thyroid hormone signaling as patients have increased serum thyroxine-to-triiodothyronine ratios and may report residual symptoms. Objective: To conduct a systematic review of studies of overt, primary hypothyroidism in which participants were treated […]

12.10.2018 | 9:43 PM
Metal Coordinated Liothyronine Tested in Rats for Hypothyroidism. PMID: 30301431
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Liothyronine (LT3) has limited short-term clinical applications, all of which aim at suppressing thyrotropin (TSH) secretion. A more controversial application is chronic administration along with levothyroxine in the treatment of hypothyroidism. Long-term treatment with LT3 is complicated by its unique pharmacokinetics that result in a substantial triiodothyronine (T3) peak in the blood three to four hours after oral […]

26.04.2018 | 9:27 PM
Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia. PMID: 29320745
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Liver-specific disruption of the type 2 deiodinase gene (Alb-D2KO) results in resistance to both diet-induced obesity and liver steatosis in mice. Here, we report that this is explained by an about 60% reduction in liver zinc-finger protein-125 (Zfp125) expression. Zfp125 is a Foxo1-inducible transcriptional repressor that causes lipid accumulation in the AML12 mouse hepatic cell […]

25.04.2018 | 10:54 AM
A DIO2 Polymorphism And Alzheimer’s Disease Dementia in African And European Americans. PMID: 29481662
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CONTEXT: A single nucleotide polymorphism in DIO2, Thr92AlaD2, has been associated with a transcriptome typically found in neurodegenerative diseases in postmortem human brain tissue. OBJECTIVE: To determine whether Thr92AlaD2 is associated with incident Alzheimer’s disease (AD). DESIGN: Population-based study; human brain tissue microarray. SETTING: Community-based cohorts from Chicago, Illinois and northeastern Illinois, as well as […]

20.04.2018 | 2:11 PM
An Online Survey of Hypothyroid Patients Reveals Prominent Dissatisfaction. PMID: 29620972
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Approximately 15% more patients taking levothyroxine (LT4) report impaired quality of life compared to controls. This could be explained by additional diagnoses independently affecting the quality of life and complicating assignment of causation. This study sought to investigate the underpinnings of reduced quality of life in hypothyroid patients and to provide data for discussion at […]

23.01.2017 | 4:36 PM
Myocardial inactivation of thyroid hormones in patients with aortic stenosis. PMID: 28095748
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Objective: To study myocardial thyroid hormone metabolism in patients with aortic valve stenosis (AS) undergoing aortic valve replacement and in patients with coronary artery disease (CAD) undergoing coronary artery bypass grafting surgery. Context: The human heart expresses the type 2 deiodinase (D2) that activates T4 to T3. At the same time, the inactivating type 3 […]

03.12.2016 | 5:44 PM
Developmental disruption of type 2 deiodinase in skeletal muscle does not impair muscle function. PMID: 27967605
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Background: Myogenesis is positively regulated by thyroid hormone (T3), which is amplified by the type 2 deiodinase (D2) activation of T4-to-T3. Global inactivation of Dio2 gene impairs skeletal muscle (SKM) differentiation and regeneration in response to muscle injury. Given that new-born and adult mice with late developmental SKM Dio2 disruption do not develop a significant […]

04.10.2016 | 5:32 PM
Is a normal TSH synonymous with “euthyroidism” in levothyroxine monotherapy? PMID: 27700539
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Context: Levothyroxine (LT4) monotherapy is the standard of care for hypothyroidism. Objective: To determine whether LT4 at doses that normalize the serum TSH is associated with normal markers of thyroid status. Design: Cross-sectional data from the US National Health and Nutrition Examination Survey (2001-2012) was used to evaluate 52 clinical parameters. LT4-users were compared to […]