26.04.2018 | 9:27 PM
Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia. PMID: PMID: 29320745

Liver-specific disruption of the type 2 deiodinase gene (Alb-D2KO) results in resistance to both diet-induced obesity and liver steatosis in mice. Here, we report that this is explained by an about 60% reduction in liver zinc-finger protein-125 (Zfp125) expression. Zfp125 is a Foxo1-inducible transcriptional repressor that causes lipid accumulation in the AML12 mouse hepatic cell […]

25.04.2018 | 10:54 AM
A DIO2 Polymorphism And Alzheimer’s Disease Dementia in African And European Americans. PMID: 29481662

CONTEXT: A single nucleotide polymorphism in DIO2, Thr92AlaD2, has been associated with a transcriptome typically found in neurodegenerative diseases in postmortem human brain tissue. OBJECTIVE: To determine whether Thr92AlaD2 is associated with incident Alzheimer’s disease (AD). DESIGN: Population-based study; human brain tissue microarray. SETTING: Community-based cohorts from Chicago, Illinois and northeastern Illinois, as well as […]

20.04.2018 | 2:11 PM
An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction. PMID: 29620972

Approximately 15% more patients taking levothyroxine (LT4) report impaired quality of life compared to controls. This could be explained by additional diagnoses independently affecting the quality of life and complicating assignment of causation. This study sought to investigate the underpinnings of reduced quality of life in hypothyroid patients and to provide data for discussion at […]

23.01.2017 | 4:36 PM
Myocardial inactivation of thyroid hormones in patients with aortic stenosis. PMID: 28095748

Objective: To study myocardial thyroid hormone metabolism in patients with aortic valve stenosis (AS) undergoing aortic valve replacement and in patients with coronary artery disease (CAD) undergoing coronary artery bypass grafting surgery. Context: The human heart expresses the type 2 deiodinase (D2) that activates T4 to T3. At the same time, the inactivating type 3 […]

03.12.2016 | 5:44 PM
Developmental disruption of type 2 deiodinase in skeletal muscle does not impair muscle function. PMID: 27967605

Background: Myogenesis is positively regulated by thyroid hormone (T3), which is amplified by the type 2 deiodinase (D2) activation of T4-to-T3. Global inactivation of Dio2 gene impairs skel-etal muscle (SKM) differentiation and regeneration in response to muscle injury. Given that new-born and adult mice with late developmental SKM Dio2 disruption do not develop a significant […]

04.10.2016 | 5:32 PM
Is a normal TSH synonymous with “euthyroidism” in levothyroxine monotherapy? PMID: 27700539

Context: Levothyroxine (LT4) monotherapy is the standard of care for hypothyroidism. Objective: To determine whether LT4 at doses that normalize the serum TSH is associated with normal markers of thyroid status. Design: Cross-sectional data from the US National Health and Nutrition Examination Survey (2001-2012) was used to evaluate 52 clinical parameters. LT4-users were compared to […]

12.08.2016 | 11:04 AM
Type 2 deiodinase disruption in astrocytes results in anxiety-depressive-like behavior in male mice. PMID: 27501182

Millions of levothyroxine-treated hypothyroid patients complain of impaired cognition despite normal TSH serum levels. This could reflect abnormalities in the type-2 deiodinase (D2)-mediated T4-to-T3 conversion, given their much greater dependence on the D2 pathway for T3 production. T3 normally reaches the brain directly from the circulation or is produced locally by D2 in astrocytes. Here […]

23.06.2016 | 12:21 PM
Thyroid hormone activation by type 2 deiodinase mediates exercise-induced PGC-1a. PMID: 27302464

Thyroid hormone (TH) promotes expression of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a), which mediates mitochondrial biogenesis and oxidative capacity in skeletal muscle (SKM). Skeletal myocytes express the type 2 deiodinase (D2), which generates T3, the active TH. To test whether D2-generated T3 plays a role in exercise-induced PGC-1a expression, male rats and mice with […]

30.10.2015 | 5:09 PM
Nutrient availability and thyroid hormone activation. PMID: 26499800

The activity of the thyroid gland is stimulated by food availability via leptin-induced TRH/TSH expression. Here we show that food availability also stimulates thyroid hormone activation by accelerating conversion of T4-to- T3 via type 2 deiodinase (D2) in mouse skeletal muscle and in a cell model transitioning from 0.1 to 10% FBS. The underlying mechanism […]