12.10.2018 | 8:37 PM
Initial tests are successful for new drug to treat hypothyroidism; clinical trial is next. PMID: 30301431

Some hypothyroid patients continue to exhibit symptoms even while they are treated with the appropriate doses of levothyroxine (L-T4). Over 10 million Americans suffer from hypothyroidism, thus the number of dissatisfied patients is not small. Recent studies show that the answer might be on how some hypothyroid patients metabolize L-T4. After reaching the bloodstream, T4 […]

29.04.2018 | 10:48 PM
Hypothyroidism. PMID: 28336049

Hypothyroidism is a common condition of thyroid hormone deficiency, which is readily diagnosed and managed but potentially fatal in severe cases if untreated. The definition of hypothyroidism is based on statistical reference ranges of the relevant biochemical parameters and is increasingly a matter of debate. Clinical manifestations of hypothyroidism range from life-threatening to no signs or symptoms. The […]

26.04.2018 | 9:27 PM
Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia. PMID: 29320745

Liver-specific disruption of the type 2 deiodinase gene (Alb-D2KO) results in resistance to both diet-induced obesity and liver steatosis in mice. Here, we report that this is explained by an about 60% reduction in liver zinc-finger protein-125 (Zfp125) expression. Zfp125 is a Foxo1-inducible transcriptional repressor that causes lipid accumulation in the AML12 mouse hepatic cell […]

25.04.2018 | 10:54 AM
A DIO2 Polymorphism And Alzheimer’s Disease Dementia in African And European Americans. PMID: 29481662

CONTEXT: A single nucleotide polymorphism in DIO2, Thr92AlaD2, has been associated with a transcriptome typically found in neurodegenerative diseases in postmortem human brain tissue. OBJECTIVE: To determine whether Thr92AlaD2 is associated with incident Alzheimer’s disease (AD). DESIGN: Population-based study; human brain tissue microarray. SETTING: Community-based cohorts from Chicago, Illinois and northeastern Illinois, as well as […]

20.04.2018 | 2:11 PM
An Online Survey of Hypothyroid Patients Reveals Prominent Dissatisfaction. PMID: 29620972

Approximately 15% more patients taking levothyroxine (LT4) report impaired quality of life compared to controls. This could be explained by additional diagnoses independently affecting the quality of life and complicating assignment of causation. This study sought to investigate the underpinnings of reduced quality of life in hypothyroid patients and to provide data for discussion at […]

20.04.2018 | 1:51 PM
Results of the 2017 Spring survey of hypothyroid patients – 12,146 individuals responded. PMID: 29620972

Current guidelines recommend daily tablets of levothyroxine at doses that normalize blood levels of TSH to treat hypothyroidism but some patients remain symptomatic despite treatment. These patients may complain of sluggishness, lethargy, sleepiness, memory problems, depression, cold intolerance, hoarseness, dry skin, body weight gain, and constipation; patients may also change physicians multiple times in pursuit […]

09.02.2017 | 1:13 AM
2017 American Thyroid Association Hypothyroidism Treatment Survey

Take the survey now!   This survey for patients with hypothyroidism has been organized by the American Thyroid Association. The results will be presented and discussed by a panel of expert physicians, scientists, and patients with hypothyroidism at the organization’s symposium in Orlando, FL later this spring. By completing this short survey, you will help […]

23.01.2017 | 5:08 PM
The unexpected hypothyroid heart in patients with normal TSH levels. PMID: 28095748

The heart of patients with stenosis of the aortic valve inactivates thyroid hormone and causes localized hypothyroidism in otherwise euthyroid individuals with normal TSH and thyroid hormones levels. This was found in a group of 23 patients with aortic stenosis that underwent corrective surgery. A second group of 35 patients with coronary artery disease undergoing […]

23.01.2017 | 4:36 PM
Myocardial inactivation of thyroid hormones in patients with aortic stenosis. PMID: 28095748

Objective: To study myocardial thyroid hormone metabolism in patients with aortic valve stenosis (AS) undergoing aortic valve replacement and in patients with coronary artery disease (CAD) undergoing coronary artery bypass grafting surgery. Context: The human heart expresses the type 2 deiodinase (D2) that activates T4 to T3. At the same time, the inactivating type 3 […]

03.12.2016 | 5:44 PM
Developmental disruption of type 2 deiodinase in skeletal muscle does not impair muscle function. PMID: 27967605

Background: Myogenesis is positively regulated by thyroid hormone (T3), which is amplified by the type 2 deiodinase (D2) activation of T4-to-T3. Global inactivation of Dio2 gene impairs skeletal muscle (SKM) differentiation and regeneration in response to muscle injury. Given that new-born and adult mice with late developmental SKM Dio2 disruption do not develop a significant […]