11.02.2014 | 9:43 PM
Doctor, should my T3 levels be measured? PMID: 25040645

The thyroid gland produces two forms of thyroid hormone: T4 and T3. Thyroid hormone has diverse biological actions and both T4 and T3 have the ability to affect virtually every tissue and organ in our bodies. T3 in particular has the most physiological relevance due to its higher attraction to the thyroid hormone receptor. On […]

13.01.2014 | 11:56 PM
Is a commonly prescribed cardiac medication affecting your thyroid? PMID: 20926587

In resting healthy individuals the heart rate normally fluctuates between 60-80 beats per minute with a regular rhythm. A number of diseases can disrupt this rhythm, with potentially serious consequences such as sudden death or brain stroke, and thus require treatment with antiarrhythmic drugs. Amiodarone is one of the most commonly prescribed antiarrhythmics in the […]

17.12.2013 | 8:51 PM
A white powder obtained on Christmas morning used to treat hypothyroidism.

Enlargements of the thyroid gland (goiter) have been noted in texts and paintings for centuries but it wasn’t until the mid-late 1800’s when physicians started to connect thyroid gland abnormalities with the constellation of clinical findings comprising the syndrome of myxedema, or hypothyroidism as it is known today. In the early 1890’s, different strategies were […]

10.12.2013 | 11:09 PM
Hypothyroidism in the brain protects from cell death in stroke. PMID: 22723689

Thyroid hormone is a key iodinated molecule that accelerates energy utilization and oxygen consumption. A steady supply of thyroid hormone to all cells is critical for maintaining a normal physiological balance in a wide range of bodily systems, including metabolic, cognitive, nervous and cardiovascular systems. However, new evidence has emerged that in some cases the […]

20.11.2013 | 9:25 AM
“It’s not your thyroid”: Facts and fiction in the thyroid-obesity relationship.

Many patients question whether they might have a thyroid problem because they have been gaining weight, even when their thyroid tests show little or no abnormalities. Given the high prevalence of thyroid diseases and obesity, could an occult thyroid dysfunction contribute to weight gain in this type of patient? Background: Thyroid hormone accelerates metabolism and […]

13.11.2013 | 9:51 AM
Genetically engineered “hyperthyroid” heart is protected against cardiac injury. PMID: 23861374

The cardiovascular system is very sensitive to thyroid hormone and patients with hyperthyroidism may experience symptoms including palpitations and changes in blood pressure. The human heart contains an enzyme that activates circulating thyroid hormone, called D2, but this enzyme is not present in adult rodent hearts. Is this an advantage or disadvantage for humans? Does […]

06.11.2013 | 5:52 PM
Is levothyroxine therapy enough for all hypothyroid patients?

The thyroid gland produces two iodine-containing hormones, T4 and T3, but much more T4 is produced than T3 on a daily basis. T4 is considered poorly active, even inactive by some, whereas T3 has the most activity due to its ability to concentrate inside the cells and activate the thyroid hormone receptors. When measured in […]

21.05.2013 | 10:51 PM
Many wonder if they have a deiodinase defect. Do you?

Serum T3 levels are remarkably stable throughout the adult life of a healthy individual. Even during iodine deficiency there is marked decrease in serum total T4, with reciprocal elevation in serum TSH, but serum T3 levels remain stable. These, and other observations, suggest that maintaining a stable serum level of T3 is a biological imperative. […]