Differential Effects of Central Leptin, Insulin, or Glucose Administration during Fasting on the Hypothalamic- Pituitary-Thyroid Axis and Feeding-Related Neurons in the Arcuate Nucleus.
The reductions in circulating levels of leptin, insulin, and glucose with fasting serve as important homeostasis signals to neurons of the hypothalamic arcuate nucleus that synthesize neuropeptide Y (NPY)/agouti-related protein (AGRP) and -MSH/cocaine and amphetamine-regulated transcript. Be- cause the central administration of leptin is capable of pre- venting the inhibitory effects of fasting on TRH […]