Extrathyroidal conversion of thyroxine to 3,5,3′-triiodothyronine in cold-acclimated thyroxine-maintained thyroidectomized rats.
Chronic exposure of rats to cold (4 degrees C) leads to thyroid gland hyperactivity as a compensatory mechanism for activating body heat production. There is increased extrathyroidal production of T3 from T4 in parallel to thyroid hormone hypersecretion. Since the 5′-deiodination (5′-D) of T4 can be modulated by thyroid hormones, it has been suggested that […]