ARCHIVE

12.04.2008 | 10:00 AM

Reawakened interest for type 3 deiodinase during illness.

Thyroid hormones influence gene expression in virtually all vertebrate tissues. Precise regulation of the active endogenous ligand, 3,5,3′- triiodothyronine (T3), is achieved by the sequential removal of iodine moieties from the thyroid hormone molecule. Type III iodothyronine deiodinase (D3) is the major inactivating enzyme terminating the action of T3 and preventing activation of the prohormone, […]

23.11.2007 | 10:38 AM

Reawakened interest in type III iodothyronine deiodinase in critical illness and injury.

Thyroid hormones influence gene expression in virtually all vertebrate tissues. Precise regulation of the active endogenous ligand, 3,5,3′- triiodothyronine (T3), is achieved by the sequential removal of iodine moieties from the thyroid hormone molecule. Type III iodothyronine deiodinase (D3) is the major inactivating enzyme terminating the action of T3 and preventing activation of the prohormone, […]

23.10.2006 | 9:56 AM

Deiodinases: implications of the local control of thyroid hormone action.

The deiodinases activate or inactivate thyroid hormone, and their importance in thyroid hormone homeostasis has become increasingly clear with the availability of deiodinase-deficient animals. At the same time, heightened interest in the field has been generated following the discovery that the type 2 deiodinase can be an important component in both the Hedgehog signaling pathway […]

11.10.2006 | 10:00 AM

Deiodinases and thyroid hormone homeostasis.

The deiodinases activate or inactivate thyroid hormone, and their importance in thyroid hormone homeostasis has become increasingly clear with the availability of deiodinase-deficient animals. At the same time, heightened interest in the field has been generated following the discovery that the type 2 deiodinase can be an important component in both the Hedgehog signaling pathway […]

13.05.2002 | 11:07 AM

Adaptive thermogenesis in hummingbirds.

The occurrence of non-shivering thermogenesis in birds has long been a controversial issue. Although birds are endothermic vertebrates, sharing with mammals (placental mammals and marsupials) a common ancestor, they do not possess brown adipose tissue or a similar type of tissue, unlike their mammalian counterparts. Some bird species are, however, able to withstand very low […]