The deiodinases activate or inactivate thyroid hormone, and their importance in thyroid hormone homeostasis has become increasingly clear with the availability of deiodinase-deficient animals. At the same time, heightened interest in the field has been generated following the discovery that the type 2 deiodinase can be an important component in both the Hedgehog signaling pathway and the G protein–coupled bile acid receptor 1–mediated (GPBAR1-mediated) signaling cascade. The discovery of these new roles for the deiodinases indicates that tissue- specific deiodination plays a much broader role than once thought, extending into the realms of developmental biology and metabolism.
Metabolic Instability of Type 2 Deiodinase Is Transferable To Stable Proteins Independently of Subcellular Localization.
Aniko Zeold, Lıvia Pormuller, Monica Dentice, John W. Harney, Cyntia Curcio-Morelli, Susana M. Tente, Antonio C. Bianco, and Balazs Gereben. Journal of Biological Chemistry. October 20, 2006. doi: 10.1172/JCI29812