We have examined the effect of hypothalamic extracts of rats fed cholesterol excess (1%) on TSH and Prl secretions from in vitro incubated pituitaries derived from normal rats. The TSH activity in the hypothalamic extracts from rats fed cholesterol excess was greater than that observed in the control extracts, indicating that increased Prl and TSH serum and pituitary concentrations detected after cholesterol feeding are due to increased release of TRH from the hypothalamus.

Hypothalamic-pituitary-thyroid function in rats undergoing cholesterol feeding.

Antonio C. Bianco, Maria T. Nunes, Carlos R. Douglas, Marco A. Tadeu and Caio Auriemo. Arq. Bras. Endocrinol. Metabol. June, 1984.

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